Welcome to the Global Protein Surface Survey (GPSS) at the Midwest Center for Structural Genomics (MCSG). The GPSS provides a comprehensive survey of the structural and functional topography derived from protein structures in the Protein Data Bank (PDB). It is a single resource to identify and explore geometrically defined surfaces and protein-hetero atom (ligands, metals, peptides and DNA) contact surfaces. In addition, functionally annotated residues identified from publicly available sources are mapped on to the structure for further analysis.

The GPSS is comprised of pre-computed libraries that attempt to capture all structural and functional surface features derived from the three-dimensional coordinates of a protein. Please refer to the help documentation for detailed description of the methods for surface identification.The surface libraries are updated with each new PDB release.

Ligand Surfaces Library† 35,122 surfaces derived from ligand protein contact residues.	Metal Surface Library† 7,432 surfaces derived from metal protein contact residues.	DNA Surfaces Library† 1,196 surfaces derived from dna-protein contact residues.
Peptide Surfaces Library† 89,253 surfaces derived from protein-peptide contacts and from protein protein interfaces.	SITES Surfaces Library† 120,000+ surfaces containing residues with functional annotation derived from PDB, SwissProt,and CSA.	CASTp Surface Library† 3,000,000+ solvent accessible and interior inacessibele surfaces calculated by the CASTp algorithm.